Samus has standard equipment. To be considered standard, it must have appeared in 2 or more games. No one time items.
Alex has all powers and abilities. (Alex Mercer is the main character from Prototype if you didn’t know.)
The Battle takes place in a city. Let’s say Samus is visiting Earth (in the suit, of course) to investigate rumors of a Blacklight outbreak. There are a few people around. Samus is not yet aware of Alex, but he sees her as a threat.
Okay, we know Alex can survive a nuke, and is very fast, strong, and can consume others to gain more power. But I will say now that attempting to consume Samus would be the worst mistake of his viral life. Samus’s Metroid cells would absorb him, netting her the Blacklight Suit.
So, The Hunter against The Virus, who’s going home?